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Tumour Specific Electroporation™

vetIQure™ – TSE
(Tumour Specific Electroporation™)

vetIQure is an innovation in oncology care and its unique and patented TSE technology ensures reversible electroporation designed for a safe and easy tumour treatment that spares the healthy tissue.

The dynamic and multi-dimensional electric pulse enhances traditional chemotherapy with a tumour- specific and controlled distribution of the electric field, which enables the coverage of the treated area. It increases the cells’ membrane permeability allowing cytotoxic drugs to enter the tumour cell.

TSE is designed to activate the immune system through the apoptosis and release of a specific tumour antigen.

TSE also makes it possible to treat non-responsive tumours and tumours in sensitive locations.

Using the customised adjustable hand-held probe, the veterinarian can choose to treat both smaller and larger areas using the same probe which also improves the ability to treat hard-to-reach locations.

The TSE technology is well-suited to treat tumours in sensitive areas where surgery is not possible such as head and neck tumours. It can be used as a primary treatment or in combination with surgery to shrink the tumour and/or treat unclean margins.

Unique advantages of vetIQure™
Tumour Specific Electroporation with its dynamic and multi-dimensional pulse is designed to spare healthy tissue and enable an immunotherapeutic effect
Sterile, single-use electrodes ensure safe and optimal performance
TSE increases the effect of cytotoxic drugs even at a lower dose than with traditional treatments and enables the treatment of tumours that do not normally respond to chemotherapy
User-friendly and portable device adapted for veterinary use
vetIQure adapts the pulse automatically and provides feedback during the treatment, which ensures safe and easy handling
Pulses delivered in multiple directions to minimise the risk of untreated areas
Improves response rate on larger tumours (> 3 cm)
The treatment can in many cases be performed without general anaesthesia

Advantages of the single-use electrodes

Sterile package to decrease the risk of infections
Due to their single-use they are always sharp and easy to insert into the tissue every time
Pulses delivered in multiple directions to minimise the risk of untreated areas
The application of new electrodes ensures that they will always be straight, maintaining a consistent and correct tip distance, thus providing a more precise electric field for each treatment

Powerful treatment enhances the effects of the cytotoxic drug

The vetIQure™ system enhances the effects of the cytotoxic drug by opening up small pores in the tumour cells, giving it direct access to the DNA of the targeted cells. Combined with the coagulation effect created by the hi-voltage electric field, the cancer cells go into apoptosis (a programmed cell death). In some cases, treatment has shown that correctly adapted dynamic pulses result in a powerful immunotherapeutic effect. The vetIQure™ dynamic feature is designed to maximise this effect. A significant advantage of treating animals with TSE is that the treatment can be performed on an outpatient basis. The active treatment with vetIQure™ takes up to 20 minutes and the whole treatment, including preparation, does not usually last longer than 45 minutes and the patient can go home the same day. This means that the treatment is very cost-effective for pet owners and insurance companies. Additionally, vetIQure™ has a handheld and easily portable design and weighs only about 6-7 kg. This makes it ideal for transporting in-between and around the veterinary hospitals and/or smaller clinics.

Current indications for treatment with TSE includes the following:

Function

With vetIQure™, traditional electroporation is combined with a dynamic and multi-directional electric field improving the current coverage throughout the treated tissue. With its IQ calibration system, vetIQure™ enables treatment using applicators of different sizes; a technology that offers the unique possibility to treat tumours in hard-to-reach places such as the oral cavity and tongue base.

Thanks to its integrated tumour database veterinarians will, in the near future, be able to exchange general treatment data with other veterinarians. By using the latest technology and components, vetIQure™ is designed to be both portable and light weight for easy transport and storage.

Multi-dimensional treatment and tumour-adapted distribution of the dynamic electrical field

Tumour Specific Electroporation™ (TSE) with a dynamic and multi-directional pulse to minimize risks of irreversible electroporation, unintentional ablation of tissue and untreated tissue areas. vetIQure™ can also treat with different diameters, depending on the size of the treatment area.

The four phases of the TSE technology

Phase 1 – Cytotoxic drug administration

The therapy begins by administrating a cytotoxic drug to the patient either intravenously or intra-tumorally.

Phase 2 – Treatment with TSE

By treating the tumour cells with TSE pulses, the cell membranes becomes reversibly permeable allowing the cytotoxic drug to enter the cells.

Phase 3 – Cytotoxic drug enclosed in the tumour cells

After each treatment cycle with TSE the cells returns to a none-permeable state. The cytotoxic drug is trapped inside the cells and create apoptosis (programmed cell death).

Phase 4 – Cell death and immunological effect

The cells DNA is broken down by the cytotoxic drug
The capillaries coagulate, which makes the cells starve and die
Activation of the immune system

Treatment of superficial tumours of any histology
Often only option for head and neck tumours
Adjuvant treatment to surgery:
– removal of micro metastases
– prevent local recurrence if resection is incomplete
Pre-surgery application to facilitate surgery or radiotherapy
Also for palliative treatment to improve quality of life

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